Scientific Research

Ilya Vinnikov

Research area:                                                                                                                                GroupPro>>

Chronic metabolic and neurodegenerative syndromes such as diabetes mellitus, obesity or Parkinson’s disease, represent a growing epidemic especially in the constantly aging western populations. They result from a failure in the interplay of environmental factors, humoral signals, extra- and intracellular enzymatic cascades, genetic and epigenetic signals in the central nervous system and in the periphery. Physiological and pathophysiological mechanisms involved in this regulation require intensive research to develop novel therapeutic strategies. The group has a strong interest in studying the role of distinct neuronal population-specific non-coding RNAs in chronic complex trait disorders. In perspective, the integration of expression and functional data from mouse and patient brain samples will provide novel insights for future genome wide association studies aiming to identify genetic variants within non-coding RNA genes and/or within the genes influenced by these RNA species.

 Keywords: neuroscience, microRNA, metabolism, hypothalamus, obesity, neurodegeneration, dopamine, Parkinson’s disease, circadian, transcription regulation and epigenetic control in eukaryotes, mouse.

Publications:

1. Domanskyi A., Alter H., Vogt M.A., Gass P., and Vinnikov I.A. (2014) Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance, Front Cell Neurosci 8.

2. Vinnikov I.A.§, Hajdukiewicz K., Reymann J., Beneke J., Czajkowski R., Roth L.C., Novak M., Roller A., Dörner N., Starkuviene V., Theis F.J., Erfle H., Schütz G., Grinevich V., and Konopka W. (2014) Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice, The Journal of Neuroscience 34, 10659-10674. §, co-corresponding author.

3. Wang H., Vinnikov I., Shahzad K., Bock F., Ranjan S., Wolter J., Kashif M., Oh J., Bierhaus A., Nawroth P., Kirschfink M., Conway E.M., Madhusudhan T., and Isermann B. (2012) The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition, Thromb Haemost 108, 1141-1153.

4. Wang H., Madhusudhan T., He T., Hummel B., Schmidt S., Vinnikov I.A., Shahzad K., Kashif M., Muller-Krebs S., Schwenger V., Bierhaus A., Rudofsky G., Nawroth P.P., and Isermann B. (2011) Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy, Blood 117, 5231-5242.

5. Kashif M., Hellwig A., Kolleker A., Shahzad K., Wang H., Lang S., Wolter J., Thati M., Vinnikov I., Bierhaus A., Nawroth P.P., and Isermann B. (2011) p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth, Development 138, 2235-2247.

6. Domanskyi A., Geissler C., Vinnikov I.A., Alter H., Schober A., Vogt M.A., Gass P., Parlato R., and Schuetz G. (2011) Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models, Faseb Journal 25, 2898-2910.

7. Seehaus S., Shahzad K., Kashif M., Vinnikov I.A., Schiller M., Wang H., Madhusudhan T., Eckstein V., Bierhaus A., Bea F., Blessing E., Weiler H., Frommhold D., Nawroth P.P., and Isermann B. (2009) Hypercoagulability Inhibits Monocyte Transendothelial Migration Through Protease-Activated Receptor-1-, Phospholipase-C beta-, Phosphoinositide 3-Kinase-, and Nitric Oxide-Dependent Signaling in Monocytes and Promotes Plaque Stability, Circulation 120, 774-U141.

8. Isermann B., Vinnikov I.A.*, Madhusudhan T., Herzog S., Kashif M., Blautzik J., Corat M.A.F., Zeier M., Blessing E., Oh J., Gerlitz B., Berg D.T., Grinnell B.W., Chavakis T., Esmon C.T., Weiler H., Bierhaus A., and Nawroth P.P. (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis, Nature Medicine 13, 1349-1358. *, equally contributed first author.

previewed in: Brownlee M. (2007) Preventing kidney cell suicide, Nature Medicine 13, 1284-1285.

highlighted in: Gilbert R.E., and Marsden P.A. (2008) Activated Protein C and Diabetic Nephropathy, New England Journal of Medicine 358, 1628-1630.

9. Zakharova M.Y., Kozyr A.V., Ignatova A.N., Vinnikov I.A., Shemiyakin I.G., and Kolesnikov A.V. (2005) Purification of filamentous bacteriophage for phage display using size-exclusion chromatography, Biotechniques 38, 194-198.

 

Book chapters:

1. Domanskyi A. and Vinnikov I.A.§ (2017) Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression?, Neural Regeneration Research 12(10), 1602-1604. §co-corresponding author.

2. Vinnikov I.A., Domanskyi A., and Konopka W.: Continuous Delivery of Oligonucleotides into the Brain. In: physiology, Humana Press, 2016: 9. , corresponding author.

3.Vinnikov I.A., Nawroth P.P., Isermann B.: Thrombomodulin-Protein-C-System, Protein Z. In: Pötzsch B., Madlener K., eds. Hämostaseologie (Haemostaseology). Berlin, Germany: Springer-Verlag, 2010: 245-258.

4. Grinevich V., Knobloch S., Roth L.C., Althammer F., Domansky A., Vinnikov I., Eliava M., Stanifer M., Boulant S.: Somatic transgenesis (Viral vectors). In: Murphy D. and Gainer H., eds. Master Classes in Molecular Neuroendocrinology: From genome to physiology. West Sussex, England: John Wiley & Sons, 2015: 243-274.

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