Scientific Research

Jing Yu

Research area:                                                                                                                    GroupPro>>
We focus on the discovery of novel mediators of therapeutic drug targets, and the relative mechanism and delivery studies. 

Publications  

(1) Giorgia Croppi, Yueyang Zhou, Rong Yang, Yunfei Bian, Mingtao Zhao, Youtian Hu, Benfang Helen Ruan, JingYu*, FangWu*, Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival, Cell Chemical Biology, 27 (2020), 1483-1499. (Cover story)

(2) Rezvan Moallemian, Ashfaq Ur. Rahman, Na Zhao, Huan Wang, Haifeng Chen, Gang Lin, Xiaojing Ma*, Jing Yu*, Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation, Biochemical Pharmacology, 177 (2020), 113964.

(3) Youtian Hu#, Lu Wang#, Xu Han, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxing Qi, Jing Yu*, Hong Liu*, and Fang Wu*, Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine gamma-Lyase, Journal of medicinal chemistry, 62 (2019), 1677-1683

(4) Li Wang#, Hao Cai#, Youtian Hu, Fan Liu, Shengshuo Huang, Yueyang Zhou, Jing Yu*, Jinyi Xu* and Fang Wu*,A pharmacological probe identifies cystathionine beta-synthase as a new negative regulator for ferroptosis, Cell death & disease, 9 (2018) 1005.

(5)Jing Yu, Sachin Dubey and Yogeshvar N. Kalia*, Needle-free cutaneous delivery of living human cells by Er:YAG fractional laser ablation, Expert opinion on drug delivery, 15 (2018) 559-566.

(6) Zhixue Du#, Jing Yu#, Fucai Li, Liyun Deng, Fang Wu, Xiangyi Huang, Jan Bergstrand, Jerker Widengren, Chaoqing Dong* and Jicun Ren*, In Situ Monitoring of p53 Protein and MDM2 Protein Interaction in Single Living Cells Using Single-Molecule Fluorescence Spectroscopy, Analytical chemistry, 90 (2018) 6144-6151.

(7) Xiling Lei#, Jing Yu#, Qi Niu, Jianhua Liu, Patrick C. Fraering and Fang Wu*, The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-beta peptides, Scientific reports, 5 (2015) 16541.

(8) Yueyang Zhou#Jing Yu#, Xiling Lei, Jianying Wu, Qi Niu, Yixuan Zhang, Hong Liu, Philipp Christen, Heinz Gehringe and Fang Wu*, High-throughput tandem-microwell assay identifies inhibitors of the hydrogen sulfide signaling pathway, Chemical communications, 49 (2013) 11782-11784.

(9) Jing Yu, Dhaval R. Kalaria, Yogeshvar N. Kalia*, Erbium:YAG fractional laser ablation for the percutaneous delivery of intact functional therapeutic antibodies, Journal of controlled release, 156 (2011) 53-59.

(10) J. Yu, Y.G. Bachhav, S. Summer, A. Heinrich, T. Bragagna, C. Bohler, Y.N. Kalia*, Using controlled laser-microporation to increase transdermal delivery of prednisone, Journal of controlled release, 148 (2010) e71-73.

(11) Jing Yu, Xiaomin Yu, Jianhua Liu*, A thermostable manganese-containing superoxide dismutase from pathogen Chlamydia pneumoniae, FEBS letters, 562 (2004) 22-26.

(12) Fang Wu, Jing Yu, Heinz Gehringe*, Inhibitory and structural studies of novel coenzyme-substrate analogs of human histidine decarboxylase, FASEB journal, 22 (2008) 890-897.

(13) Jie Ren# , Yuanyuan Zhang#, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu* and Weidong Zhang*, Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb, ACS chemical biology, 9 (2014) 897-903.

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