Scientific Research


Research area:                                                                                                   GroupPro>>  
       In eukaryotic cells, transcription is delicately regulated by transcription regulators, including transcription factors, co-factors, histone modifiers, and non-coding RNAs. Dysregulations of transcription, including both mutations of transcription regulators and mutations in the binding sequences of transcription factors, are found in human diseases, including cancers. We are working on transcriptional regulation of hematopoiesis and tumorigenesis, and are particularly interested in how transcription regulators, including PAF1 complex (PAF1C), the super elongation complex (SEC), MLL1, GATA1, and RUNX1, regulate hematopoiesis under physiological conditions, and how related transcriptional dysregulations induce human cancers.
Publications (Updated 2016.01)


  1. Yu, M., Yang, W., Ni, T., Tang, Z., Nakadai, T., Zhu, J., and Roeder, R.G. (2015) RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. Science 350, 1383-1386.
  2. Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S.K., Soltis, A., Yu, M., Vemula, S., et al. (2015). Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem cells 33, 925-938.
  3. Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. H., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A., and Vakoc, C. R. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation, Genes Dev 27, 2648-2662.
  4. Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., and Vakoc, C. R. (2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia, Proc Natl Acad Sci U S A 110, 3901-3906.
  5. Wan, M., Gu, H., Wang, J., Huang, H., Zhao, J., Kaundal, R. K., Yu, M., Kushwaha, R., Chaiyachati, B. H., Deerhake, E., and Chi, T. (2013) Inducible mouse models illuminate parameters influencing epigenetic inheritance, Development 140, 843-852.
  6. Yu, M., Mazor, T., Huang, H., Huang, H. T., Kathrein, K. L., Woo, A. J., Chouinard, C. R., Labadorf, A., Akie, T. E., Moran, T. B., Xie, H., Zacharek, S., Taniuchi, I., Roeder, R. G., Kim, C. F., Zon, L. I., Fraenkel, E., and Cantor, A. B. (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors, Mol Cell 45, 330-343.
  7. Amigo, J. D., Yu, M., Troadec, M. B., Gwynn, B., Cooney, J. D., Lambert, A. J., Chi, N. C., Weiss, M. J., Peters, L. L., Kaplan, J., Cantor, A. B., and Paw, B. H. (2011) Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis, Mol Cell Biol 31, 1344-1356.
  8. Yu, M., Riva, L., Xie, H., Schindler, Y., Moran, T. B., Cheng, Y., Yu, D., Hardison, R., Weiss, M. J., Orkin, S. H., Bernstein, B. E., Fraenkel, E., and Cantor, A. B. (2009) Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis, Mol Cell 36, 682-695.
  9. Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W., Trede, N. S., Davidson, A. J., Barut, B. A., Zhou, Y., Wojiski, S. A., Traver, D., Moran, T. B., Kourkoulis, G., Hsu, K., Kanki, J. P., Shah, D. I., Lin, H. F., Handin, R. I., Cantor, A. B., and Paw, B. H. (2009) The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish, Blood 114, 4654-4663.
  10. Huang, H., Yu, M., Akie, T. E., Moran, T. B., Woo, A. J., Tu, N., Waldon, Z., Lin, Y. Y., Steen, H., and Cantor, A. B. (2009) Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development, Mol Cell Biol 29, 4103-4115.
  11. Yu, M., Wan, M., Zhang, J., Wu, J., Khatri, R., and Chi, T. (2008) Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development, Proc Natl Acad Sci U S A 105, 3873-3878.
  12. Yu, M., Yu, M., and Ru, B. (2004) Expression of an antibody-targeted plasminogen activator in Escherichia coli using chemically induced stress responses, Biotechnol Lett 26, 1629-1634.
  13. Yu, M., Yu, M., and Ru, B. (2004) Enhanced expression of an antibody-targeted plasminogen activator in Escherichia coli by fusion to decorsin, Biotechnol Lett 26, 717-721.


Book chapters and invited reviews

  1. Yu M, Cantor AB. Megakaryopoiesis and thrombopoiesis: an update on cytokines and lineage surface markers. Methods Mol Biol. 2012;788:291-303.


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